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Researchers decode tertiary structure of DNA aptamer–ATP complex and improve binding affinity

DNA aptamers are powerful molecular tools in biosensing, bioimaging and therapeutics. However, a limited understanding of their tertiary structures and binding mechanisms hinders their further ...
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Researchers create ADP- or ATP-containing molecules with improved yield and consistency

Researchers used a novel phosphate-activation reagent, 2-MeImIm-Cl, in an improved coupling reaction to increase the yield of ADP- or ATP-containing molecules. Unlike traditional reactions, the ...
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Mitochondria shift toward the cell edge in response to glucose

Unlike our organs, cell organelles such as mitochondria are not fixed in place, but when, where, how, and why organelles move ...
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Pioneering new method reveals glucose channeling, charting the fine structure of energy metabolism inside active cells

3D electron tomography reveals glycogen particles (purple) clustered on the surface of lipid droplets (yellow), closely associated with endoplasmic reticulum membranes (blue) and mitochondria (red), ...

Mitochondria migrate toward the cell membrane in response to high glucose levels, study shows

Unlike our organs, cell organelles such as mitochondria are not fixed in place, but when, where, how, and why organelles move ...