Endotoxin refers to a component of the outer cell membrane of Gram-negative bacteria called lipopolysaccharide (LPS). LPS is the biologically active portion of naturally occurring endotoxin complexes.

A recent guidance update from the U.S. Food and Drug Administration (FDA) on pyrogen and endotoxins testing represents a missed opportunity to meaningfully advance alternatives to horseshoe-crab-blood ...

When we discuss bacterial infections, we often think of exotoxins – those soluble proteins actively secreted by bacteria – while overlooking endotoxins, which are more insidious but equally dangerous.

THE role of bacterial endotoxins in the pathogenesis of infections due to endotoxin-containing bacteria is not clear. It is commonly assumed that endotoxin is a major factor in determining toxicity ...

Surf on a beach at sunset features a horseshoe crab upside down in the water and several others nearby. Regulatory changes may make the pharmaceutical industry less reliant on horseshoe crabs for ...

Escherichia coli is widely considered the most cost-effective bacterial system for recombinant protein expression. Consequently, it is broadly used. Nonetheless, it has its limitations as an ...

Bacteria can be found everywhere—even sometimes in clean rooms. That’s a problem for manufacturers of drugs and medical devices that are injected or implanted. Even if manufacturers can remove the ...