Direct consequences of the fact that DNA molecules store and transfer genetic information are that lesions sustained by cellular DNA inevitably result in information loss and that error-free repair of ...

Vaccine effectiveness against coronavirus disease 2019 (Covid-19) wanes over time, and boosters are now recommended for residents of the United States starting at the age of 12 years. 1 Clinical ...

The Cas9 endonuclease can be targeted to genomic sequences by programming the sequence of an associated single guide RNA (sgRNA). For unknown reasons, the activity of these Cas9–sgRNA combinations ...

The prevalence of homologous recombination DNA damage repair (HR-DDR) deficiencies among all tumor lineages is not well characterized. Therapy directed toward homologous recombination DDR deficiency ...

Use of an RNA-based HRD signature significantly expands the fraction of patients with prostate cancer who may derive benefit from poly (ADP-ribose) polymerase inhibitors (PARPis) compared with using ...

When DNA breaks, cells must repair it accurately to prevent harmful mutations. Researchers have discovered that during a key repair process called homologous recombination, the cell uses loops in its ...

Many different vaccinations have been developed and approved worldwide against severe acute respiratory syndrome 2 (SARS-CoV-2) in a remarkably short period. Although mass vaccinations have resulted ...

A research collaboration based in Kumamoto University (Japan) has clarified how homologous chromosome pairing--a process necessary for sperm and egg formation where paternally- and maternally-derived ...

Sensitivity to ionizing radiation is compelling evidence that BRCA1-and BRCA2-deficient cells are defective in repair of DSBs. As discussed above, 2 separate pathways play major roles in DSB repair in ...

To the Editor: In their interesting paper, "Homologous-Blood Syndrome during Extracorporeal Circulation in Man," which was published in the June 20 issue of the Journal, Litwak et al. showed that the ...