Researchers at the Francis Crick Institute have outlined the structure and function of a protein complex that is required to repair damaged DNA and protect against cancer. Using cryo-electron ...

Researchers have revealed the mechanism of the drug valemetostat shown to be effective in treating certain types of cancer by targeting a protein modification (histone methylation) silencing the ...

The retinoblastoma protein (pRB) is a tumor suppressor protein that can act as a transcriptional repressor, but the mechanisms underlying this function are unclear and controversial. In the July 17 ...

Valemetostat reduces methylated histone levels by inhibiting EZH1/2 and induces expression of tumor suppressor genes, resulting in a sustained clinical benefit. In some patients receiving long-term ...