Sample preparation plays a crucial role in bioanalytical analysis involving chromatography. Insufficient sample preparation, such as skipping protein precipitation, phospholipid removal (PLR), ...

The success of any large-scale proteomics study is fundamentally determined at the sample preparation stage, which serves as the critical bridge between the biological system and the analytical ...

This detailed overview explains the technical mechanisms of LC-MS proteomics, including peptide separation, ion generation, ...

In clinical and pharmaceutical research, reliable quantification of large sample cohorts is essential for meaningful investigations. Liquid chromatography–mass spectrometry (LC–MS)-based quantitative ...

Proteomics is a unique source for a vast pool of information that is also very complex when it comes to analysis. In the last decade and a half, there have been significant advancements for detection, ...

Evosep has introduced the Evosep Eno™, a high-throughput separation tool for LC-MS–based proteomics workflows. The system supports analysis of more than 500 samples per day, enabling quantification of ...

New users of the LC/MS laboratory and Sample Preparation Lab are required to engage in hands-on orientation to facility operations (e.g., laboratory access, scheduling, general use of equipment, ...

Therapeutic proteins are subject to deamidation, oxidation, glycosylation and other post-translational modifications (PTMs). These finishing touches are not merely ornamental, they can alter essential ...

Hydrogen/deuterium exchange-mass spectrometry (HDX-MS) is a powerful technique for studying protein dynamics, however its widespread application has been constrained by high sample consumption and ...