Scientists discovered that lowering a specific molecule helps microglia switch into a protective state that quiets brain inflammation in Alzheimer’s. A small group of these cells seems to have an ...

Alzheimer's disease (AD) is a highly debilitating neurodegenerative disease characterized by the progressive loss of memory and decline of mental functions. Earlier research has uncovered some of the ...

Recursion, Roche, and its Genentech subsidiary have unveiled the latest product of their nearly four-year artificial intelligence (AI) drug discovery collaboration, a whole-genome map of specialized ...

Arrhythmias, or irregular heart rhythms, are common complications of HCM. The thickened heart muscle disrupts the electrical pathways that coordinate heartbeat, leading to arrhythmias. Atrial ...

MINNEAPOLIS — Readouts of data on an experimental drug for hypertrophic cardiomyopathies showed the agent appeared safe and effective in long-term treatment and can significantly improve exercise ...

Panel A shows a cross-section of a normal heart (top) and an endomyocardial biopsy sample from a normal heart (bottom; with hematoxylin and eosin staining) that shows normal histologic characteristics ...

Mavacamten is approved to treat adults with symptomatic obstructive hypertrophic cardiomyopathy (HCM). However, its effects in nonobstructive HCM remain uncertain. We conducted a phase 3, ...

In one of two trials that substantially expand clinical evidence with myosin inhibitors in the treatment of hypertrophic cardiomyopathy (HCM), a next-in-class agent beat beta-blockers in first-line ...

It’s hard to overstate how crucial microglia are to brain health. These humble immune cells quietly patrol the central nervous system, clearing debris, pruning synapses, and maintaining myelin. But ...

Mouse microglia got a genetic tune-up. On 9 June in Nature Aging, researchers led by Warren G. Tourtellotte at Cedars-Sinai Medical Center in Los Angeles reported that expressing human ...

A new way to deliver disease-fighting proteins throughout the brain may improve the treatment of Alzheimer's disease and other neurological disorders, according to scientists. By engineering human ...

The hearts of people with hypertrophic cardiomyopathy are thicker, and must beat more forcefully to pump out blood into the body. This can lead to a variety of symptoms, which may appear only ...