All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes are expressed in ...

Scientists discovered that lowering a specific molecule helps microglia switch into a protective state that quiets brain inflammation in Alzheimer’s. A small group of these cells seems to have an ...

Alzheimer's disease (AD) is a highly debilitating neurodegenerative disease characterized by the progressive loss of memory and decline of mental functions. Earlier research has uncovered some of the ...

Single-celled organisms have more complex DNA epigenetic code than multicellular life, researchers discover by Queen Mary, University of London edited by Sadie Harley, reviewed by Robert Egan Editors' ...

Single-cell RNAseq analysis for retinal CD45 + CD11b + cells 0, 1, 4 and 7 days after ocular injury. ATAC-seq motif analysis for discovery of putative transcription factors regulating monocyte ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. Microglia are mononuclear phagocytes in the CNS and play ...

Recursion, Roche, and its Genentech subsidiary have unveiled the latest product of their nearly four-year artificial intelligence (AI) drug discovery collaboration, a whole-genome map of specialized ...

Background: Microglia, the innate immune cells of the central nervous system (CNS), are the first cellular responders to stroke. Microglia populate the brain during development and age throughout the ...

It’s hard to overstate how crucial microglia are to brain health. These humble immune cells quietly patrol the central nervous system, clearing debris, pruning synapses, and maintaining myelin. But ...

(Left) Correction of pathogenic Csf1r mutation by Mr BMT effectively rescues pathological changes in the brain, motor impairment and cognitive decline in ALSP mice. (Right) tBMT-mediated microglia ...

Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Glioblastoma (GBM), a highly aggressive and malignant form of primary adult brain cancer ...