We show that the depen-dence of synaptic modification on spike timing provides a mech-anism that can lead to competitive Hebbian learning without requiring global intracellular signaling, or preset activity …

Synaptic plasticity is a fundamental mechanism by which the brain adapts and learns, playing a crucial role in shaping our cognitive functions, including learning and memory.

Principally, synaptic plasticity refers to the strengthening or weakening of synaptic contacts as a result of increasing or decreasing activity levels of the neurons involved in a particular neural circuit.

We studied the dynamics of systems consolidation in simple circuit architectures with two sites of plasticity, one in an early-learning and one in a late-learning brain area.

May 26, 2023 · Synapse organizing proteins are multifaceted molecules that coordinate the complex processes of brain development and plasticity at the level of individual synapses. Their importance is …

Abstract Synaptic plasticity is a fundamental mechanism underlying learning and memory, reflecting the brain's ability to adapt and reorganize in response to experiences. This process is characterized by …

In this review, we compare and contrast structural changes at the synapse during both implicit and explicit memory consolidation, as well as the molecular signaling pathways that initiate the learning …