A Tale of Two T Cells—Slowing Tau Spread, Shredding White Matter
Jul 11, 2025 · With T cells sidelined in these CD8 knockouts, tau pathology went on the offensive. By 30 weeks of age, phospho-tau had spread deeper into the brain than in CD8-intact controls (image …
Tau (PHF-1) | ALZFORUM
Recognizes tau doubly phosphorylated at serines 396 and 404 Immunoreactivity seen in Alzheimer's disease and other tauopathies but not controls Used to assess the progression of tau pathology in …
Tau (CP-13) - ALZFORUM
Feb 7, 2024 · This monoclonal antibody, generated against paired helical filaments (PHFs) isolated from Alzheimer’s brains, recognizes tau phosphorylated at serine 202. Recognizes tau phosphorylated at …
12 Phosphorylation-Mimicking Mutations Twist Tau into AD Filaments
Sep 23, 2025 · By mutating select residues of tau into aspartate to mimic phosphorylation, the scientists zeroed in on a combination of 12 residues that, when mutated, goad tau into pairing up into helical …
New Biomarkers Catch Tau Before It Tangles | ALZFORUM
Feb 18, 2025 · Detecting toxic forms of tau before they weave into dense thickets of tangles could pave the way for earlier diagnosis and treatment of tauopathies, including Alzheimer’s disease. In the …
Phospho-Tau Might Take Down Viruses | ALZFORUM
Jan 9, 2026 · Phosphorylated tau isn’t just pathological junk; it helps the brain defend against viral infections. So claim scientists led by Rudolph Tanzi and William Eimer at Massachusetts General …
Cell-Based Assay Matches Tau Strains to Neuropathological Diagnosis
Jan 30, 2025 · Tau, Incorporated. A library of tau mutants generated by alanine substitution (red residues, left), was transduced into biosensor cell lines containing pre-existing tau fibril strains. The …
New Role for Tau: Making Lipid Droplets in Glia? | ALZFORUM
Oct 22, 2024 · Tau plays an essential role in the production of these droplets, according to a paper in the October Nature Neuroscience. Using a combination of fly and mammalian cell models, scientists …
Large Tau-PET Studies Confirm: Tangles Foretell Decline
Jul 16, 2025 · Two studies analyzed tau-PET scans from thousands of participants in dozens of cohorts. Tangle prevalence increased with age among cognitively normal people, but decreased among those …
When Loaded With Granulovacuolar Bodies, Neurons Combat Tau
Mar 9, 2026 · In mice, the number of GVB-positive neurons rises with tauopathy. GVB+ neurons oppose tauopathy by cranking out ribosomal machinery, upping protein synthesis Casein kinase 1δ prompts …